Levaquin
Levaquin (generic name: Levofloxacin) is an antibiotic that stops multiplication of bacteria by preventing the reproduction and repair of their genetic material (DNA). It is in a class of antibiotics called fluoroquinolones, a class that includes ciprofloxacin (Cipro), norfloxacin (Noroxin), ofloxacin (Floxin), trovafloxacin (Trovan), and lomefloxacin (Maxaquin). Levofloxacin was approved by the FDA in 1996.
Minerals with 2 or 3 positive charges, called divalent or trivalent ions, respectively, can attach to levofloxacin and other fluoroquinolones and prevent their absorption from the intestine into the blood. Therefore, such products (containing iron, calcium, zinc, or magnesium) as well as antacids, should be taken at least 2 hours before or 2 hours after levofloxacin. Other drugs which contain these ions and which can similarly interact with levofloxacin include sucralfate (Carafate) and didanosine, dDI.
Taking non-steroidal anti-inflammatory drugs (NSAIDs) with levofloxacin may increase the risk of CNS stimulation, resulting in over-excitation. There have been reports of changes in blood sugar in patients treated with other fluoroquinolones and antidiabetic agents. Other fluoroquinolones have been reported to increase blood levels of theophylline (Theodur), warfarin (Coumadin), and cyclosporine (Sandimmune; Neoral). There have not yet been similar reports with levofloxacin.
Levaquin possible side effects
The most frequently reported side events are nausea or vomiting (1 out of every 12 persons), diarrhea (1 out 20), headache (1 out 20), and constipation (1 out of 30). Less common side effects include difficulty sleeping, dizziness, abdominal pain, rash, abdominal gas, and itching.
Levaquin Levofloxacin as well as other antibiotics in the fluoroquinolone class of antibiotics, has been associated with tendinitis and even rupture of tendons, particularly the Achilles tendon. Some physicians recommend that their patients discontinue vigorous exercise while they are taking fluoroquinolone antibiotics.